Document 0879
 DOCN  M9540879
 TI    A natural antisense RNA derived from the HIV-1 env gene encodes a
       protein which is recognized by circulating antibodies of HIV+
       individuals.
 DT    9504
 AU    Vanhee-Brossollet C; Thoreau H; Serpente N; D'Auriol L; Levy JP; Vaquero
       C; Oncologie et Immunologie des Maladies Retrovirales, INSERM U152,;
       Paris, France.
 SO    Virology. 1995 Jan 10;206(1):196-202. Unique Identifier : AIDSLINE
       MED/95133151
 AB    A naturally occurring antisense RNA, transcribed in the opposite
       direction and complementary to the envelope transcript, was identified
       in various cell lines chronically infected with HIV-1. In T cells, the
       antisense transcript is constitutively expressed and enhanced by
       activation with phorbol myristate acetate. The open reading frame
       corresponding to the antisense transcript, when expressed in vitro,
       encodes a protein with an apparent molecular mass of 19 kDa. Antibodies
       against this protein have been detected in several sera of HIV+
       individuals and not in any of the noninfected control sera. These
       results indicate, for the first time, that expression of an antisense
       open reading frame most likely accompanies the HIV infection cycle in
       humans.
 DE    Base Sequence  Cell Line  Gene Products, env/*GENETICS/IMMUNOLOGY
       *Genes, env  Human  HIV Antibodies/*IMMUNOLOGY  HIV
       Seropositivity/BLOOD/*IMMUNOLOGY  HIV-1/*GENETICS/IMMUNOLOGY  Molecular
       Sequence Data  RNA, Antisense/*GENETICS  RNA, Messenger/GENETICS
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).