Document 0886
 DOCN  M9540886
 TI    The common mucosal immune system: from basic principles to enteric
       vaccines with relevance for the female reproductive tract.
 DT    9504
 AU    McGhee JR; Xu-Amano J; Miller CJ; Jackson RJ; Fujihashi K; Staats HF;
       Kiyono H; Department of Microbiology, UAB Medical Center, Birmingham,;
       Alabama 35294.
 SO    Reprod Fertil Dev. 1994;6(3):369-79. Unique Identifier : AIDSLINE
       MED/95132851
 AB    The realization that induction of immune responses at mucosal surfaces
       may prevent colonization, invasion or dissemination of pathogenic
       microorganisms has spurred intensive efforts to develop vaccines which
       elicit effective mucosal immunity. In this paper, recent results are
       discussed for mice given cholera toxin as both an immunogen and as an
       adjuvant for inducing both humoral and gastrointestinal mucosal immune
       responses. Oral administration of cholera toxin alone or with a
       co-administered protein vaccine tetanus toxoid induces a strong T helper
       type 2 (TH2) cell response in both Peyer's patches and spleen. Both
       serum IgG and secretory IgA antibodies specific for cholera toxin or for
       the co-administered protein tetanus toxoid were induced. When
       administered parentally, however, no mucosal antibody responses were
       evident and a mixed TH1- and TH2-type CD4+ T cell response was noted in
       the spleen. Various vectors are being employed in an effort not only to
       induce mucosal immune responses but also to direct the response to a
       TH1-type response, thought to promote strong cell-mediated immune
       responses, or to a TH2-type response for maximum B cell antibody
       responses. The ability to manipulate the TH cell responses may provide a
       more rational approach for the design of vaccines. Although lymphoid
       tissues of the female reproductive tract differ from that of the gut,
       many of the strategies and evolving principles may be directly
       applicable to the development of vaccines designed to prevent sexually
       transmitted diseases.
 DE    Administration, Oral  Animal  Antibodies/METABOLISM  Cholera
       Vaccine/*ADMINISTRATION & DOSAGE/IMMUNOLOGY  Female  Genitalia,
       Female/*IMMUNOLOGY  Human  IgA/METABOLISM  IgG/METABOLISM  Immunity
       Mice  Mice, Inbred C3H  Mice, Inbred C57BL  Mucous Membrane/DRUG
       EFFECTS/*IMMUNOLOGY  Peyer's Patches/DRUG EFFECTS/*IMMUNOLOGY
       Spleen/DRUG EFFECTS/*IMMUNOLOGY  Support, U.S. Gov't, P.H.S.  Tetanus
       Toxoid/ADMINISTRATION & DOSAGE  Th2 Cells/DRUG EFFECTS/*IMMUNOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).