Document 0888
 DOCN  M9540888
 TI    Active gypsy/Ty3 retrotransposons or retroviruses in Caenorhabditis
       elegans.
 DT    9504
 AU    Britten RJ; Division of Biology, California Institute of Technology,
       Corona; del Mar, 92625.
 SO    Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):599-601. Unique Identifier :
       AIDSLINE MED/95132647
 AB    A gypsy/Ty3-class retrotransposon (Cer1) is integrated in the DNA of
       Caenorhabditis elegans chromosome III. It is 8865 nt in length and has
       492-nt long terminal repeats that are identical in DNA sequence. There
       is an exceptionally long (6819 nt) open reading frame uninterrupted by
       frame-shift mutations in the period since the insertion, which must
       therefore have been rather recent. Alignment with other gypsy-class
       elements and with retroviruses indicates that an env gene occupies the
       3' 1.2 kb of the open reading frame. A search through GenBank has
       uncovered two additional gypsy-class elements from C. elegans that are
       very closely related in DNA sequence to this insert and are transcribed.
       Since gypsy of Drosophila has been shown to be an infectious element, it
       is possible that retrovirus-like gypsy elements are active in C.
       elegans.
 DE    Animal  Caenorhabditis elegans/*GENETICS  DNA, Helminth/*GENETICS
       Evolution  Genes, env/GENETICS  Mutagenesis  Reading Frames/GENETICS
       Repetitive Sequences, Nucleic Acid/GENETICS  Retrotransposons/*GENETICS
       Retroviridae/*GENETICS  Reverse Transcriptase/GENETICS  Support, U.S.
       Gov't, P.H.S.  Transcription, Genetic  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).