Document 0919
 DOCN  M9540919
 TI    [Studies on local immune response in mouse model of experimental
       Escherichia coli intrauterine infections]
 DT    9504
 AU    Satoh T; Kumamoto Y; Hirose T; Department of Urology, School of
       Medicine, Sapporo Medical; University.
 SO    Kansenshogaku Zasshi. 1994 Nov;68(11):1381-9. Unique Identifier :
       AIDSLINE MED/95130999
 AB    Studies were conducted to elucidate the immune cell response at
       infection sites by performing immunostaining of immune cells with a
       monoclonal antibody in an experimental Escherichia coli (E. coli) mouse
       uterine infection model. 1. The incidence of uterine infection by E.
       coli decreased with the passage of time: 4/4 on Day 1, 4/6 on Day 3, 2/6
       on Day 7, and 1/6 on each of Days 14 and 21. It was surmised that
       clearance of the bacteria from the infection sites was being carried out
       by immune cells. 2. Beginning from infection Day 1, the infected uterine
       tissue was observed to undergo a moderate degree of invasion by
       neutrophils, macrophages, CD4+ T cells, CD8+ T cells and IgA+ B cells.
       Then, beginning from infection Day 3, there was a mild degree of
       invasion of the infected uterine tissue by IgM+ B cells and IgG+ B
       cells. The number of neutrophils in the tissue decreased beginning from
       infection Day 14, but the degree of invasion of the infected tissue by
       the other kinds of immune cells remained almost constant through
       infection Day 21. 3. A comparison was made of the immune responses to
       local infection by E. coli, and Chlamydia trachomatis (C. trachomatis),
       an intracellular parasite. It was found that the invasion of the
       infection site by immune cells occurred earlier in the case of E. coli
       infection than C. trachomatis infection. In addition, the C. trachomatis
       infection site was observed to contain greater numbers of macrophages
       and CD8+ T cells play important roles in the immune defense at sites of
       infection by C. trachomatis.
 DE    Animal  Antibodies, Bacterial/ANALYSIS  Chlamydia trachomatis/IMMUNOLOGY
       Chlamydia Infections/IMMUNOLOGY  Comparative Study  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Disease Models, Animal  English Abstract
       Escherichia coli Infections/*IMMUNOLOGY  Female  Macrophages/IMMUNOLOGY
       Mice  Mice, Inbred BALB C  Uterine Diseases/*IMMUNOLOGY/*MICROBIOLOGY
       JOURNAL ARTICLE

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