Document 0942
 DOCN  M9540942
 TI    Correlation between viral DNA load and serum anti p19 antibody
       concentration in symptomless human T-lymphotropic virus type-I
       (HTLV-I)-infected individuals.
 DT    9504
 AU    Morand-Joubert L; Mariotti M; Reed D; Petit JC; Lefrere JJ; Service de
       Bacterio-virologie, Hopital Saint-Antoine, Paris,; France.
 SO    Int J Cancer. 1995 Jan 17;60(2):156-9. Unique Identifier : AIDSLINE
       MED/95130223
 AB    In order to determine whether serum anti-human T-cell lymphotropic virus
       type I (HTLV-I) antibody concentration is correlated with cellular viral
       DNA load, these 2 biological parameters were established in 22
       symptomless HTLV-I carriers. The proviral copy (PVC) number was
       determined through quantificative polymerase chain reaction. Specific
       antibody titers were determined by Western blot with the end-point
       dilution method; the quantification of each antibody was performed
       through ScanBlot by determination of the peak height of each
       Western-blot band. A positive correlation was observed between the PVC
       number and the titer of total antibodies. When the association between
       the peak height of each antibody and the PVC number was studied, a
       significant positive correlation was observed only with anti-p 19.
       Further evaluation through follow-up studies of symptomless HTLV-I
       individuals is needed to clarify the value of anti-HTLV-I antibody titer
       as a predictor of disease progression.
 DE    Adult  Carrier State/*VIROLOGY  DNA, Viral/*ANALYSIS  Female  Human
       HTLV-I/GENETICS  HTLV-I Antibodies/*BLOOD  HTLV-I Infections/*VIROLOGY
       Male  Middle Age  Proviruses/GENETICS  JOURNAL ARTICLE

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