Document 0943
 DOCN  M9540943
 TI    Monoclonal gammopathies in asymptomatic HIV-seropositive donors.
 DT    9504
 AU    Kandle SK; Murthy A; Ghatole MP; Jahagirdar VL; Department of
       Microbiology, Dr V.M. Medical College, Solapur.
 SO    Indian J Med Res. 1994 Dec;100:268-71. Unique Identifier : AIDSLINE
       MED/95130179
 AB    Twenty two HIV antibody ELISA reactive serum samples from blood donors
       were subjected to Western blot (WB) test, out of which 12 sera were
       found WB positive, five were WB-indeterminate and five were WB-negative.
       Electrophoresis on agar gel and polyacrylamide gel (PAG) was done in all
       ELISA reactive sera. Two of the 12 WB-positive and one of the five
       WB-indeterminate donors showed presence of monoclonal (M) immunoglobulin
       component and which was identified as of IgG isotype on
       immunoelectrophoresis (IEP). Sera with 'M' component demonstrated
       decreased levels of IgA and IgM whereas other sera showed polyclonal
       increase of immunoglobulins. The paraproteins observed in these patients
       are possibly a reflection of B-cell overactivation.
 DE    Human  HIV Seropositivity/*COMPLICATIONS  Immunoelectrophoresis
       Paraproteinemias/*ETIOLOGY  JOURNAL ARTICLE

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