Document 0955
 DOCN  M9540955
 TI    Indium-111 labelled pooled human immunoglobulin imaging to monitor the
       efficacy of specific therapy for Pneumocystis carinii pneumonia.
 DT    9504
 AU    Buscombe JR; Khalkhali I; Mason GR; Rauh D; Meatherall J; Oyen WJ;
       Corstens FH; Royal Free Hospital and School of Medicine, London, UK.
 SO    Eur J Nucl Med. 1994 Oct;21(10):1148-50. Unique Identifier : AIDSLINE
       MED/95129583
 AB    Functional imaging is ideally suited to monitoring the effect of
       specific therapy on disease processes. In this pilot study five patients
       with AIDS and Pneumocystis carinii pneumonia (PCP) were imaged with
       Indium-111 labelled pooled human immunoglobulin (111In-HIG) during
       infection and after therapy for PCP. The lung activity of 111In-HIG,
       measured as a lung/heart ratio, was calculated in a study performed
       during infection with PCP and after therapy. In all five patients the
       lung/heart ratio of 111In-HIG was reduced after treatment. The mean
       reduction in heart/lung ratio was 27% (range 12%-53%). If these results
       are confirmed by a larger study, 111In-HIG will be useful in monitoring
       the response of PCP to therapy in patients with AIDS.
 DE    Adult  AIDS-Related Opportunistic Infections/DRUG THERAPY/*RADIONUCLIDE
       IMAGING  Human  Immunoglobulins/*DIAGNOSTIC USE  Indium
       Radioisotopes/*DIAGNOSTIC USE  Lung/RADIONUCLIDE IMAGING  Male  Pilot
       Projects  Pneumonia, Pneumocystis carinii/DRUG THERAPY/*RADIONUCLIDE
       IMAGING  Radioimmunodetection/*METHODS  Retrospective Studies  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).