Document 0958
 DOCN  M9540958
 TI    Peripheral blood lymphocyte subsets in multiple myeloma and monoclonal
       gammopathy of undetermined significance.
 DT    9504
 AU    Tienhaara A; Pelliniemi TT; Department of Haematology, Turku University
       Central Hospital,; Finland.
 SO    Clin Lab Haematol. 1994 Sep;16(3):213-23. Unique Identifier : AIDSLINE
       MED/95129334
 AB    Peripheral blood lymphocyte subsets were analysed by flow cytometry and
       compared among 43 patients with untreated multiple myeloma (MM), 16
       patients with monoclonal gammopathy of undetermined significance (MGUS)
       and 26 controls. The age and sex distributions of the patients and
       controls were comparable, which is important, since in the controls
       there was a significant effect of age and/or sex on the number of CD3+,
       CD57+, CD8+57+, CD16+ and CD3-56+ lymphocyte subsets, and on the
       CD4+/CD8+ and CD4+Leu-8+/CD4+ ratios. In MM, the number of CD8+ and
       CD57+ cells and the CD4+/CD8+ ratio were related to the clinical stage.
       The number of CD20+, CD3+, CD4+, CD16+ and CD3-56+ cells and the
       CD3+/CD20+ ratio were significantly different in MM patients compared to
       age- and sex-matched controls as was the number of CD3+ and CD4+ cells
       of MGUS patients compared to controls. Further, there were significant
       differences in the CD3+/CD20+ ratio between MM and MGUS patients and
       between stage I MM and MGUS. The role of peripheral blood lymphocyte
       subsets in differentiating monoclonal gammopathies merits further study.
 DE    Age Factors  Aged  Aged, 80 and over  Comparative Study  CD4 Lymphocyte
       Count  Diagnosis, Differential  Female  Flow Cytometry  Human
       Immunophenotyping  *Lymphocyte Count  *Lymphocyte Subsets  Male  Middle
       Age  Monoclonal Gammopathies, Benign/*BLOOD/DIAGNOSIS  Multiple
       Myeloma/*BLOOD/DIAGNOSIS/PATHOLOGY  Neoplasm Staging  Sex Factors
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

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