Document 0963
 DOCN  M9540963
 TI    The challenge of drug-resistant tuberculosis.
 DT    9504
 AU    Reichman LB; New Jersey Medical Center, National Tuberculosis Center,
       Newark; 07107.
 SO    Cleve Clin J Med. 1994 Nov-Dec;61(6):431-7. Unique Identifier : AIDSLINE
       MED/95129255
 AB    CLINICAL ISSUES: After declining for decades, the incidence of
       tuberculosis is again increasing, and strains resistant to multiple
       drugs are appearing. The greatest increases in infection have been in
       blacks and Hispanics. The disease is most aggressive in patients
       infected with human immunodeficiency virus and in patients receiving
       immunosuppressive therapy; diagnosis may be difficult in these groups.
       Resistance to antituberculosis drugs is the result of inadequate
       regimens or of patients not complying with prescribed regimens.
       RECOMMENDATIONS: The current epidemic can be stopped, but this will
       require a serious commitment by the public, the medical community,
       government, and industry. Physicians must prevent the spread of
       tuberculosis, detect people who are infected, treat infected people
       preventively with isoniazid, and, in people with active disease, rapidly
       establish the diagnosis and use adequate, directly supervised, four-drug
       regimens to treat it. Convenient combined preparations and programs to
       directly supervise the taking of medications are needed.
 DE    Antitubercular Agents/*THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/EPIDEMIOLOGY/PREVENTION &  CONTROL  Cross
       Infection/EPIDEMIOLOGY/PREVENTION & CONTROL  Human  Patient Compliance
       Tuberculosis, Multidrug-Resistant/EPIDEMIOLOGY/*PREVENTION &  CONTROL
       Tuberculosis, Pulmonary/EPIDEMIOLOGY/*PREVENTION & CONTROL  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).