Document 0975
 DOCN  M9540975
 TI    [Cervical pathology and immunodepression]
 DT    9504
 AU    Quereux C; Hourdequin P; Saniez D; Remy G; Service de
       gynecologie-obstetrique, Hopital Maison Blanche,; CHU, Reims.
 SO    Contracept Fertil Sex. 1994 Dec;22(12):771-6. Unique Identifier :
       AIDSLINE MED/95128349
 AB    The Human Papilloma Virus is often involved in the pathogenesis of
       cervical lesions. A local or systemic immunodeficiency allows neoplasia
       outbreaks. We do not know if immunodepression only allows the virus to
       persist, or if the HPV induces a local immunodeficiency. Large warts are
       often associated with pregnancy, but cervical cancers are not increased
       in pregnant women. Induced immunodeficiency (among transplanted
       patients), or AIDS increase the rate of CIN and cervical cancers. The
       more serious the immunodeficiency is, the more multifocal and recurrent
       the lesions are. We have to look for an immunodepression and for AIDS
       when we observe multifocal or recurrent lesions of the cervix, specially
       when the lesions do not regress under correct treatment. Immunodeficient
       women would benefit from closer care of their cervix. We think that
       combine therapy (e.g. laser and local interferon) would be more
       efficient in case of immunodeficiency.
 DE    Cervix Diseases/*ETIOLOGY/IMMUNOLOGY/VIROLOGY  English Abstract  Female
       Human  HIV Seropositivity/*COMPLICATIONS/IMMUNOLOGY  Immunocompromised
       Host/*IMMUNOLOGY  *Papillomavirus, Human  Papovaviridae
       Infections/*ETIOLOGY/IMMUNOLOGY/VIROLOGY  Recurrence  Risk Factors
       Tumor Virus Infections/*ETIOLOGY/IMMUNOLOGY/VIROLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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