Document 0984
 DOCN  M9540984
 TI    Molecular aspects concerning antigen oligopeptide selection by MHC class
       I molecules.
 DT    9504
 AU    Drugarin D; Simon Z; Sulea T; Tatu CA; Department of Physiology,
       University of Medicine and Pharmacy,; Timisoara, Romania.
 SO    Roum Arch Microbiol Immunol. 1993 Oct-Dec;52(4):267-75. Unique
       Identifier : AIDSLINE MED/95128009
 AB    T cells can recognize the antigen only if it is associated with self MHC
       molecules on the surface of antigen presenting cells (APC). There are
       several characteristic parameters defining interaction of MHC molecule
       with antigenic peptides giving circumstances for specific antigen
       presentation and an individualized immune response. Here are assessed
       some size and conformational parameters of the peptides presented by MHC
       class I molecules-lengths, widths, van der Waals volumes and
       surfaces-using COSMIC 2.0 software. The peptides derived from HIV gp 160
       are obtained from literature and are known to be active and inactive in
       a cytotoxicity assay. An increased tendency for beta- or beta-like
       structures and volumes close to those of the MHC binding site are
       encountered in the case of active peptides.
 DE    Amino Acid Sequence  Antigen-Presenting Cells/IMMUNOLOGY
       Antigens/GENETICS/*IMMUNOLOGY  Antigens, Surface/GENETICS/IMMUNOLOGY
       Gene Products, env/GENETICS/IMMUNOLOGY  Genes, MHC Class
       I/GENETICS/*IMMUNOLOGY  Human  HIV Antigens/GENETICS/IMMUNOLOGY
       HIV-1/GENETICS/IMMUNOLOGY  Ligands  Molecular Sequence Data
       Oligopeptides/GENETICS/*IMMUNOLOGY  Protein
       Precursors/GENETICS/IMMUNOLOGY  T-Lymphocytes/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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