Document 0985
 DOCN  M9540985
 TI    Mantle cell lymphoma with the features of mucosa-associated lymphoid
       tissue (MALT) lymphoma in an HTLV-I-seropositive patient.
 DT    9504
 AU    Shibata K; Shimamoto Y; Nakano S; Miyahara M; Nakano H; Yamaguchi M;
       Department of Internal Medicine, Saga Medical School, Japan.
 SO    Ann Hematol. 1995 Jan;70(1):47-51. Unique Identifier : AIDSLINE
       MED/95127836
 AB    A case of small lymphocytic B-cell lymphoma with seropositivity for
       human T-cell leukemia virus type I (HTLV-I), whose clinical features
       were closely related to those of mucosa-associated lymphoid tissue
       (MALT) lymphoma, is presented. The neoplastic cells of the lymph node
       were immunologically positive for CD5, in addition to several B-cell
       markers, but negative for CD10, and cytogenetically carried a
       t(11;14)(q13;q32). These findings were fully consistent with so-called
       mantle cell lymphoma (MCL). In addition to the lymph nodes and bone
       marrow, multiple extranodal sites including lacrimal and salivary
       glands, lung and stomach (where MALT is present) were occupied by
       lymphoma cells. These extranodal lesions were immunologically identical
       to the lymph nodes (CD5(+), CD10(-)), but histologically showed
       lymphoepithelial lesions (LEL) characteristic of MALT lymphoma. These
       findings suggest a possible relationship between MCL and MALT lymphoma,
       and the neoplastic cells are thought to originate from the CD5-positive
       B cells, which are present near the areas across the mantle and marginal
       zones. Furthermore, HTLV-I-infection, which appears to create an
       immunodeficient state or modulate the B-cell response, is thought to
       play a role in B-cell lymphomagenesis.
 DE    Antigens, CD/ANALYSIS  Case Report  Human  HTLV-I/IMMUNOLOGY  HTLV-I
       Antibodies/BLOOD  HTLV-I Infections/COMPLICATIONS/IMMUNOLOGY/*PATHOLOGY
       Lymphoma, B-Cell/COMPLICATIONS/IMMUNOLOGY/*PATHOLOGY/*VIROLOGY
       Lymphoma, Mucosa-Associated Lymphoid Tissue/COMPLICATIONS/
       IMMUNOLOGY/*PATHOLOGY/*VIROLOGY  Male  Membrane
       Metallo-Endopeptidase/ANALYSIS  Middle Age  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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