Document 0987
 DOCN  M9540987
 TI    Advances in the biology of gynecologic cancer.
 DT    9504
 AU    Gotlieb WH; Berek JS; Department of Obstetrics and Gynecology, UCLA
       School of Medicine,; Jonsson Comprehensive Cancer Center 90024-1740.
 SO    Curr Opin Oncol. 1994 Sep;6(5):513-8. Unique Identifier : AIDSLINE
       MED/95127783
 AB    This review discusses recent insights into the roles of the p53
       tumor-suppressor gene and growth factors in the development of ovarian
       cancer and describes the genes implicated in familial ovarian cancer
       syndromes related to the MSH2 (Lynch II) and BRCA1 (breast and ovarian
       cancer) genes. Evidence of the monoclonality of ovarian cancer, which
       contrasts with data supporting the polyclonal origin of primary
       peritoneal carcinoma, is presented. Finally, the roles of the human
       papillomavirus and the HIV virus in the etiology of cervical cancer are
       analyzed in view of the growing importance of this HIV-associated cancer
       and the poor outcome in these patients.
 DE    Cervix Dysplasia/VIROLOGY  Cervix Neoplasms/*VIROLOGY  Female  Human
       Ovarian Neoplasms/*GENETICS/IMMUNOLOGY  Papillomavirus, Human  Protein
       p53/GENETICS  Tumor Stem Cells  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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