Document 0989
 DOCN  M9540989
 TI    Biologic aspects of AIDS-related lymphoma.
 DT    9504
 AU    Shibata D; Department of Pathology, University of Southern California,;
       School of Medicine 90033.
 SO    Curr Opin Oncol. 1994 Sep;6(5):503-7. Unique Identifier : AIDSLINE
       MED/95127781
 AB    Lymphoma is one of the defining manifestations of AIDS. Most of these
       lymphoproliferations are high-grade B-cell non-Hodgkin's lymphoma.
       Unlike lymphoproliferations that arise in other settings of
       immunodeficiency, HIV-related lymphomas have a variable association with
       Epstein-Barr virus (EBV) and also contain alterations in c-myc and p53.
       EBV infection appears to precede clonal expansion, and its latent
       expression pattern (Epstein-Barr nuclear antigen1+/Epstein Barr nuclear
       antigen 2-/latent membrane protein+) is unique among non-Hodgkin's
       lymphomas. Both EBV types A and B are present in HIV-related lymphomas.
       Mutations in c-myc include translocations and point mutations. Other
       altered loci include ras and bcl-6. Although all of these somatic
       alterations can be detected in lymphomas arising in the general
       population, their accumulation in a relatively short period (6 to 8
       years) after HIV infection suggests an acceleration of underlying
       mechanisms.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Human
       Lymphoma/GENETICS/*PHYSIOPATHOLOGY/*VIROLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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