Document 0990
 DOCN  M9540990
 TI    Pathogenesis of HIV-related Kaposi's sarcoma.
 DT    9504
 AU    Miles SA; University of California, Los Angeles.
 SO    Curr Opin Oncol. 1994 Sep;6(5):497-502. Unique Identifier : AIDSLINE
       MED/95127780
 AB    Infection with HIV-1 is associated with a 7000-fold increase in the
       incidence of Kaposi's sarcoma (KS). Some studies suggest that the risk
       of KS in HIV infection is increased with certain sexual practices and
       that a sexually transmitted agent could be involved. Exposure to this
       agent apparently alters both the morphology and growth regulation of the
       KS progenitor cells. These changes include the expression of the
       different cytokine receptors and the acquisition of autocrine growth
       loops. Perturbations of multiple cytokines during HIV infection,
       including oncostatin-M, interleukin-1 beta, and tumor necrosis
       factor-alpha, alter the subsequent growth of KS. These studies suggest
       that control of cytokine perturbations or the underlying HIV-1 infection
       could result in a significant reduction in the growth rate of
       AIDS-related KS.
 DE    Cell Division  Human  HIV Infections/*COMPLICATIONS  Risk Factors
       Sarcoma, Kaposi's/IMMUNOLOGY/*PHYSIOPATHOLOGY/VIROLOGY  Tumor Stem Cells
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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