Document 0991
 DOCN  M9540991
 TI    Epidemiology of AIDS-related malignancies.
 DT    9504
 AU    Rabkin CS; Viral Epidemiology Branch, National Cancer Institute,
       Bethesda,; MD 20892.
 SO    Curr Opin Oncol. 1994 Sep;6(5):492-6. Unique Identifier : AIDSLINE
       MED/95127779
 AB    HIV infection is known to increase the incidence of Kaposi's sarcoma and
       non-Hodgkin's lymphoma. Kaposi's sarcoma preferentially affects
       homosexual men and risk varies by geographic area, suggesting there is
       an environmental cofactor for Kaposi's sarcoma in addition to HIV.
       Despite intensive investigation, the responsible cofactor has not been
       conclusively identified. HIV-associated non-Hodgkin's lymphoma affects
       all HIV transmission groups, and non-Hodgkin's lymphoma risk increases
       with duration of HIV infection and age. Epstein-Barr virus has been
       implicated in the pathogenesis of this tumor, but the precise mechanisms
       have not been worked out. Cervical cancer and anal cancer have a less
       certain association with HIV infection and immunodeficiency, although
       epithelial dysplasia at these sites does seem to be HIV-related.
       Children with HIV infection are additionally affected by increased
       incidence of leiomyosarcoma and benign leiomyoma, whereas adults with
       HIV infection do not seem particularly susceptible to this tumor,
       perhaps because of hormonal or growth-promoting factors. Apart from
       these specific disease associations, HIV infection and related
       immunodeficiency do not result in a generalized tumor diathesis.
       Prevention and management of HIV-associated cancers are becoming
       increasingly important as the HIV epidemic continues to grow.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Anus
       Neoplasms/EPIDEMIOLOGY  Cervix Neoplasms/EPIDEMIOLOGY  Female  Hodgkin's
       Disease/EPIDEMIOLOGY  Human  Lymphoma, Non-Hodgkin's/EPIDEMIOLOGY
       Neoplasms/*EPIDEMIOLOGY/VIROLOGY  Sarcoma, Kaposi's/EPIDEMIOLOGY  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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