Document 1001
 DOCN  M9541001
 TI    [Structural and functional relationships demonstrated by the study of V3
       loop heterogeneity]
 DT    9504
 AU    Ruta S; Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
 SO    Rev Roum Virol. 1993 Jul-Dec;44(3-4):289-304. Unique Identifier :
       AIDSLINE MED/95127487
 AB    Data obtained from genomic sequence analysis of the gp 120 V3 loop show
       that some of the phenotype features depend on the modifications produced
       in the amino acid sequence of this region. Phenotypical characterization
       of HIV isolates is based on their sensitivity to neutralizing
       antibodies, the appearance of virus variants showing unusual tropism,
       higher cytopathogenicity in vitro and modified virulence in vivo, etc.
       Sequencing data published since now concern strains from the
       Euro-American area only, the other geographical areas being neglected.
       So, these informations support some relations between structure and
       function, but don't allow a prediction about the evolutive capacity of
       HIV strains, the distinction between conserved and variable regions nor
       the understanding of medical signification of some specific genomic
       changes. Three aspects important for clinical evolution of the disease
       are discussed in detail: genomic changes in V3 encoding sequence
       associated with virulence, changes associated with neurotropism for
       macrophages, changes conditioning sensitivity to neutralizing
       antibodies.
 DE    Antigenic Determinants/GENETICS/IMMUNOLOGY  Antigenic
       Variation/GENETICS/IMMUNOLOGY  Antigens, Viral/GENETICS/IMMUNOLOGY
       English Abstract  *Genetic Heterogeneity  Genotype  HIV Envelope Protein
       gp120/*GENETICS/IMMUNOLOGY  HIV-1/*GENETICS/IMMUNOLOGY/PATHOGENICITY
       Structure-Activity Relationship  Viral Envelope
       Proteins/GENETICS/IMMUNOLOGY  Virulence/GENETICS/IMMUNOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

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