Document 1003
 DOCN  M9541003
 TI    Neuroophthalmological examination in children with AIDS.
 DT    9504
 AU    Constantinescu AF; Ruta SM; Constantinescu SN; Cernescu C; Department of
       Ophthalmology, Witting Hospital, Bueharest,; Romania.
 SO    Rev Roum Virol. 1993 Jul-Dec;44(3-4):187-93. Unique Identifier :
       AIDSLINE MED/95127475
 AB    Evaluation of HIV disease status includes physical examination
       (anthropomorphic measurements, neurological assessment, etc.) and
       laboratory examination. Consideration should be given to changes from
       baseline values, age adjusted normal values and the rapidity of changes.
       Here we compare results of neuroophthalmologic assessment with Western
       Blo (WB) profiles in cerebrospinal fluids (CSF) of 54 children with
       AIDS. Children were classified by Denver Developmental Screening Test
       (DDST) administration in encephalopathy positive (n = 44) and
       encephalopathy negative (n = 10) groups. Neuroophthalmological
       examination which included nine items with good test-retest reliability
       showed that two of them (nystagmus on following and visual memory
       impairment) appeared early in the encephalopathy free group and
       correlated with the loss of some gag band in Western Blot (lower gag
       score). No correlation was however, found with respect to p24 antigen
       level in cerebrospinal fluid, a marker which reflects CNS viral load.
 DE    Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/
       COMPLICATIONS/*DIAGNOSIS  AIDS Dementia Complex/CEREBROSPINAL
       FLUID/DIAGNOSIS  Biological Markers/CEREBROSPINAL FLUID  Child,
       Preschool  Comparative Study  Eye Diseases/CEREBROSPINAL
       FLUID/*DIAGNOSIS/ETIOLOGY  Human  HIV Antibodies/CEREBROSPINAL FLUID
       HIV Core Protein p24/CEREBROSPINAL FLUID  HIV Infections/CEREBROSPINAL
       FLUID/COMPLICATIONS/DIAGNOSIS  *HIV-1/IMMUNOLOGY  Infant  Nervous System
       Diseases/CEREBROSPINAL FLUID/*DIAGNOSIS/ETIOLOGY  Neurologic Examination
       Neuropsychological Tests  Psychomotor Performance  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).