Document 1010
 DOCN  M9541010
 TI    Cutaneous disease resembling mycosis fungoides in HIV-infected patients
       whose skin and blood cells also harbor proviral HTLV type I.
 DT    9504
 AU    Zucker-Franklin D; Pancake BA; Friedman-Kien AE; New York University
       Medical Center, New York 10016.
 SO    AIDS Res Hum Retroviruses. 1994 Sep;10(9):1173-7. Unique Identifier :
       AIDSLINE MED/95127300
 AB    Two homosexual HIV-infected patients with lymphocyte counts of < 50
       presented with intense pruritis, hyperpigmentation, and skin lesions
       clinically suggestive of the cutaneous T cell lymphoma, mycosis
       fungoides. On light microscopy, the skin biopsies were difficult to
       interpret because of the sparseness of the lymphocytic infiltrates.
       However, electron microscopy revealed typical Sezary cells in the
       peripheral blood and skin. Cultures of blood mononuclear cells of one of
       the patients generated HTLV-I-like particles. Although both patients
       lacked antibodies to HTLV, their blood and skin specimens proved to
       harbor tax and pol HTLV-I proviral sequences as shown by the polymerase
       chain reaction and Southern blot analysis. Dual infection with HIV and
       HTLV should be considered in the diagnostic work-up of patients at risk,
       even in the absence of demonstrable antibodies. Dual infections could
       result in clinical manifestations and evolution of disease not
       anticipated in patients who harbor only one of these retroviruses.
 DE    Adult  AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY  Blood
       Cells/*VIROLOGY  Blotting, Southern  Case Report
       Dermatomycoses/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY  Genes, pol  Genes, pX
       Homosexuality, Male  Human  HTLV-I/GENETICS/*ISOLATION & PURIF  Male
       Microscopy, Electron  Middle Age  Mycosis
       Fungoides/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY  Polymerase Chain Reaction
       Proviruses/GENETICS/ISOLATION & PURIF  Skin/ULTRASTRUCTURE/*VIROLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).