Document 1024 DOCN M9541024 TI Phylogenesis and genetic complexity of the nonhuman primate retroviridae. DT 9504 AU Franchini G; Reitz MS Jr; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892. SO AIDS Res Hum Retroviruses. 1994 Sep;10(9):1047-60. Unique Identifier : AIDSLINE MED/95127286 AB The three known groups of nonhuman primate retroviruses (simian immunodeficiency virus, simian T cell lymphotropic/leukemic virus type I, and simian foamy virus) are thought to have equivalent human counterparts. This is clearly the case with human immunodeficiency virus types 1 and 2, the causative agents of acquired immunodeficiency syndrome, and with human T cell lymphotropic/leukemia virus type I (HTLV-I), which causes T cell leukemia and a progressive form of myelopathy (tropical spastic paraparesis/HTLV-I-associated myelopathy), and HTLV-II. However, the presence of spumaviruses (foamy viruses) in humans remains uncertain. Data accumulated in the last 5 years suggest the possibility that the human retroviruses are indeed the result of transmission of simian retroviruses to humans. In this article we attempt to parallel the genetic features of the simian retroviridae with their human counterparts and argue for the possibility of horizontal transmission of these viruses from monkeys to humans. DE Animal Comparative Study Genes, Regulator Genes, Viral Hominidae/VIROLOGY Human *Phylogeny Primates/*VIROLOGY Retroviridae/*CLASSIFICATION/*GENETICS SIV/CLASSIFICATION/GENETICS STLV/GENETICS JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).