Document 1028
 DOCN  M9541028
 TI    Cytokines and the Th1/Th2 paradigm in transplantation.
 DT    9504
 AU    Nickerson P; Steurer W; Steiger J; Zheng X; Steele AW; Strom TB; Harvard
       Medical School, Beth Israel Hospital, Boston.
 SO    Curr Opin Immunol. 1994 Oct;6(5):757-64. Unique Identifier : AIDSLINE
       MED/95127114
 AB    With studies elucidating the cytokine programs associated with T-cell
       activation, allograft rejection and tolerance induction, the Th1/Th2
       paradigm has become a unifying model to explain the observed cytokine
       profiles. The proof that these cytokines mediate allograft tolerance,
       however, is at best indirect. More recent studies highlighting the
       redundant and pleiotropic nature of cytokine networks suggest that the
       Th1/Th2 paradigm may not be sufficient to explain fully the mechanisms
       underlying allograft tolerance.
 DE    Animal  Cytokines/*IMMUNOLOGY  Graft Rejection/IMMUNOLOGY  Human  Immune
       Tolerance/IMMUNOLOGY  Models, Immunological  Signal Transduction
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Th1
       Cells/*IMMUNOLOGY  Th2 Cells/*IMMUNOLOGY  Transplantation
       Immunology/*IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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