Document 0006
 DOCN  M9550006
 TI    Inhibition of gp120-CD4 interaction and human immunodeficiency virus
       type 1 infection in vitro by pyridoxal 5'-phosphate.
 DT    9505
 AU    Guo L; Heinzinger NK; Stevenson M; Schopfer LM; Salhany JM; Department
       of Pathology and Microbiology, University of Nebraska; Medical Center,
       Omaha 68198-5120.
 SO    Antimicrob Agents Chemother. 1994 Oct;38(10):2483-7. Unique Identifier :
       AIDSLINE MED/95142602
 AB    Pyridoxal 5'-phosphate and related compounds were tested for their
       ability to inhibit gp120-CD4 interaction and human immunodeficiency
       virus infection in vitro. The results show that pyridoxal 5'-phosphate
       is a unique CD4 antagonist whose antiviral potency derives from the
       presence of both lysine-reactive and anionic substituents.
 DE    Cells, Cultured  CD4-Positive T-Lymphocytes/*METABOLISM
       DIDS/PHARMACOLOGY  DNA/BIOSYNTHESIS  HIV Envelope Protein
       gp120/*METABOLISM  HIV-1/*DRUG EFFECTS  Pyridoxal
       Phosphate/*PHARMACOLOGY  Reverse Transcriptase/ANTAGONISTS & INHIB
       Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S.
       Gov't, P.H.S.  Virus Replication/DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).