Document 0015
 DOCN  M9550015
 TI    Immunologic evaluation of 24 month course of sublingual immunotherapy.
 DT    9505
 AU    Tari MG; Mancino M; Madonna F; Buzzoni L; Parmiani S; Servizio Autonomo
       di Allergologia E Fisiopatologia Respiratoria,; Arienzo, Caserta, Italy.
 SO    Allergol Immunopathol (Madr). 1994 Sep-Oct;22(5):209-16. Unique
       Identifier : AIDSLINE MED/95141994
 AB    58 patients under 12 years of age, positive to mites (Dermatophagoides
       pteronyssinus and D. farinae) according to prick, in vitro specific IgE
       and challenge tests, suffering from asthma and rhinitis, have been
       randomly assigned on a double blind basis to receive per os either a
       biologically standardized extract of mites (active therapy TA = 30
       patients) or a saline buffered solution (placebo TP = 28 patients). The
       serologic results are interesting. The specific IgE level differences of
       significance are, in comparison with the placebo group. In particular,
       we did observe the increase of the specific IgE level in the placebo
       group during the autumn, whereas after 12 months and after 24 months of
       active treatment there was a clear (p < 0.01) decline in serum specific
       IgE antibody. In the active group, there was a significant increase in
       IgG antibodies level after 12 and 24 months and a significant increase
       in IgG4 level after 24 months. In the placebo group, the level of IgG
       antibodies was unchanged. In the actively treated patients, a
       significant increase of CD8+ values and a significant reduction of the
       ratio CD4+/CD8+ was observed.
 DE    Administration, Sublingual  Animal  Antibody Specificity
       Asthma/ETIOLOGY/IMMUNOLOGY/*THERAPY  Child  Child, Preschool  CD4-CD8
       Ratio  *Desensitization, Immunologic  Double-Blind Method  Female
       Glycoproteins/*ADMINISTRATION & DOSAGE/IMMUNOLOGY  Human
       IgE/BLOOD/IMMUNOLOGY  IgG/BLOOD/IMMUNOLOGY  Lymphocyte Count  Lymphocyte
       Subsets  Male  Mites/*IMMUNOLOGY  Rhinitis, Allergic,
       Perennial/ETIOLOGY/IMMUNOLOGY/*THERAPY  Treatment Outcome  CLINICAL
       TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

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