Document 0024
 DOCN  M9550024
 TI    Broadly reactive HIV-2 and SIVmac specific antibody-dependent cellular
       cytotoxicity in immunized and infected cynomolgus monkeys.
 DT    9505
 AU    von Gegerfelt A; Nilsson C; Putkonen P; Broliden K; Department of
       Virology, Karolinska Institute, Stockholm, Sweden.
 SO    Vaccine. 1994 Oct;12(13):1203-8. Unique Identifier : AIDSLINE
       MED/95141682
 AB    Antibody-dependent cellular cytotoxicity (ADCC) was analysed in groups
       of cynomolgus monkeys that had been immunized with either HIV-2 (strains
       SBL6669 or SBL-K135) or SIVmac. HIV-2- and SIVmac-infected monkeys were
       also studied for ADCC. Sequential serum samples were collected from the
       animals, which were followed for 1 to 3 years. Sera from the
       HIV-2-immunized monkeys had ADCC against both homologous and
       heterologous HIV-2 strains as well as cross-reactivity against
       SIVmac-infected target cells. This broadly reactive ADCC response could
       be detected within the first weeks after immunization. Homologous ADCC
       was also seen in seven of eight SIVmac-immunized monkeys which were all
       protected from later challenge with SIVmac or SVsm. ADCC titres
       sometimes decreased after a few months if the immunized monkeys were not
       boosted whereas most of the HIV-2-and SIVmac-infected monkeys developed
       a rapid and persistent ADCC response. The presence of ADCC, like the
       presence of neutralization in previous studies, did not predict whether
       the immunized monkeys would be protected upon challenge with live virus.
 DE    Animal  Antibodies, Viral  *Antibody-Dependent Cell Cytotoxicity  AIDS
       Vaccines/ADMINISTRATION & DOSAGE  Cross Reactions  Gene Products,
       env/*IMMUNOLOGY  HIV Antibodies  HIV Infections/IMMUNOLOGY
       HIV-2/*IMMUNOLOGY  Immunization  Immunization, Secondary  In Vitro
       Macaca fascicularis  Retroviridae Proteins, Oncogenic/*IMMUNOLOGY
       Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Species
       Specificity  Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.
       SIV/*IMMUNOLOGY  Time Factors  Viral Fusion Proteins/*IMMUNOLOGY  Viral
       Vaccines/ADMINISTRATION & DOSAGE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).