Document 0030
 DOCN  M9550030
 TI    Survival of MHC-deficient mouse heterotopic cardiac allografts.
 DT    9505
 AU    Campos L; Naji A; Deli BC; Kern JH; Kim JI; Barker CF; Markmann JF;
       Department of Surgery, Hospital of the University of; Pennsylvania,
       Philadelphia 19104.
 SO    Transplantation. 1995 Jan 27;59(2):187-91. Unique Identifier : AIDSLINE
       MED/95141380
 AB    The immunologic mechanisms involved in the destruction of murine cardiac
       allografts were evaluated using MHC-deficient mice. Specifically, we
       examined the survival of immediately vascularized heterotopic adult
       cardiac grafts deficient in MHC class I, MHC class II, or both MHC class
       I and II antigens following transplantation to allogeneic hosts. We
       observed indefinite cardiac graft survival when donors lacked MHC class
       II or both MHC I and II antigens. In parallel experiments, we studied
       the survival of cardiac grafts harvested from normal donors in
       recipients severely depleted of either CD4 (class II-deficient mice) or
       CD8 (class I-deficient mice) T cells. Graft survival was dramatically
       prolonged in the absence of CD4 but not CD8 T cells. Collectively, our
       results demonstrate that the interaction of host CD4 T cells with donor
       class II antigens is critical to the rejection of murine cardiac grafts.
 DE    Animal  Coronary Vessels/PHYSIOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Graft Survival/*IMMUNOLOGY  Haplotypes  Heart
       Transplantation/*IMMUNOLOGY  Histocompatibility Antigens Class
       I/IMMUNOLOGY  Histocompatibility Antigens Class II/IMMUNOLOGY/METABOLISM
       Lymphocyte Transformation/IMMUNOLOGY  Major Histocompatibility
       Complex/*IMMUNOLOGY  Mice  Mice, Inbred Strains  Neck  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes/IMMUNOLOGY  Transplantation, Heterologous
       *Transplantation, Heterotopic  Transplantation, Homologous  JOURNAL
       ARTICLE

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