Document 0054
 DOCN  M9550054
 TI    Synthesis of some new heterobicyclic compounds containing
       spiro-1,2,4-triazine moiety as potential anti-HIV and anticancer agents.
 DT    9505
 AU    Abdel-Rahman RM; Seada M; Fawzy M; el-Baz I; Department of Chemistry,
       Faculty of Education, Ain-Shams; University, Roxy, Cairo, Egypt.
 SO    Pharmazie. 1994 Nov;49(11):811-4. Unique Identifier : AIDSLINE
       MED/95140786
 AB    A number of heterobicyclic compounds such as 1,3,5-thiazine,
       thiazolidinone, pyrimidine, pyrimidinedione, imidazole, quinazolinone
       and 1,2,4-triazinone derivatives have been sythesized by reaction of
       1,6-dihydro-3(2H)-thioxo-6-spiro-(9'- fluorene)-1,2,4-triazin-5(4H)-one
       (1) with sulphur/nitrogen compounds in neutral or alkaline media.
       Structure elucidation of the new compounds have been carried out with
       the help of elemental analysis and spectral data. Some of these
       compounds were tested for in vitro anti HIV and anticancer activities.
 DE    Antineoplastic Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Antiviral
       Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  HIV/*DRUG EFFECTS  Nuclear
       Magnetic Resonance  Spectrophotometry, Infrared  Spectrophotometry,
       Ultraviolet  Spectrum Analysis, Mass  Triazines/*CHEMICAL
       SYNTHESIS/PHARMACOLOGY  Tumor Cells, Cultured  Zidovudine/PHARMACOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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