Document 0075
 DOCN  M9550075
 TI    Nephrotoxic serum nephritis in nude rats: the role of cell-mediated
       immunity.
 DT    9505
 AU    Kuroda T; Kawasaki K; Oite T; Arakawa M; Shimizu F; Department of
       Immunology, Niigata University School of Medicine,; Japan.
 SO    Nephron. 1994;68(3):360-5. Unique Identifier : AIDSLINE MED/95140137
 AB    The role of T cell-mediated immunity in the early phase of nephrotoxic
       serum nephritis (NTN) was examined by transfer of pan T, CD8-positive,
       and CD4-positive cells. The disease was induced by transferring rabbit
       gamma-globulin (RGG)-sensitized T cells to nude (rnu/rnu) rats
       pretreated with a subnephritogenic dose (a dose insufficient to cause
       proteinuria) of nephrotoxic serum. Mild but abnormal proteinuria was
       detected, and macrophages showed significant accumulation in glomeruli.
       Transfer of not only RGG-sensitized CD4-positive cells but also
       CD8-positive cells separated by the T cell markers OX8 and OX38 using
       the panning method caused an increased accumulation of macrophages in
       isolated glomeruli. No host antibody against rabbit immunoglobulins was
       demonstrated either in glomeruli by immunofluorescence or sera by ELISA
       in the early disease phase. These findings support a pathological role
       of T cells in initiation of glomerular injury in NTN.
 DE    Animal  CD4-Positive T-Lymphocytes/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Enzyme-Linked Immunosorbent Assay  Female
       Fluorescent Antibody Technique  IgG/*ANALYSIS  Immunity, Cellular
       Immunotherapy, Adoptive  Kidney Glomerulus/IMMUNOLOGY/PATHOLOGY
       Macrophages/PATHOLOGY  Nephritis/ETIOLOGY/*IMMUNOLOGY/PATHOLOGY
       Proteinuria/ETIOLOGY/IMMUNOLOGY  Rats  Rats, Inbred ACI  Rats, Mutant
       Strains  Rats, Nude  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).