Document 0076
 DOCN  M9550076
 TI    Routine vaccination in HIV-infected patients: a review.
 DT    9505
 AU    Borleffs JC; Schneider MM; Department of Internal Medicine, Utrecht
       University Hospital,; Netherlands.
 SO    Neth J Med. 1994 Dec;45(6):244-9. Unique Identifier : AIDSLINE
       MED/95140114
 AB    This paper reviews the literature from 1988 to November 1993 on the
       effectiveness of routine vaccination of HIV-infected adults. Data on the
       clinical benefit of vaccination in this particular group of patients are
       not available. In general, HIV-infected patients have suboptimal
       immunological responses to vaccines. In particular, an impaired
       responsiveness is found in patients with fewer than 200 x 10(6) CD4+
       cells per litre. Consequently, it seems prudent to offer active
       immunization to HIV-infected subjects who are relatively
       immunocompetent. However, the usefulness of vaccination in those
       subjects who have a low CD4+ cell count is doubtful.
 DE    Human  HIV Infections/BLOOD/IMMUNOLOGY/*THERAPY  *Vaccination/ADVERSE
       EFFECTS/METHODS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).