Document 0077
 DOCN  M9550077
 TI    Immunological and virological markers determining progression to AIDS.
 DT    9505
 AU    Schellekens PT; Koot M; Roos MT; Tersmette M; Miedema F; Department of
       Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red
       Cross Blood Transfusion Service, Amsterdam.
 SO    Neth J Med. 1994 Dec;45(6):238-43. Unique Identifier : AIDSLINE
       MED/95140113
 AB    Infection with the human immunodeficiency virus (HIV-1) results in a
       severe immunodeficiency characterized by a depletion of CD4+ T-helper
       cells. Furthermore it is well documented that in asymptomatic persons
       the number of CD4+ cells is also a good predictor of progression to
       AIDS. However, persons with similar CD4+ cell counts may differ with
       regard to clinical progression. For this reason the development of
       additional markers predictive of disease progression is of major
       clinical importance. In this review three additional progression markers
       are discussed: rate of decline of CD4+ cells, T-cell reactivity and HIV
       biological phenotype. Besides their usefulness as independent
       progression markers they also provide insight into the
       immunopathological mechanisms responsible for the final development of
       AIDS.
 DE    Biological Markers  *CD4 Lymphocyte Count  Disease Progression  Human
       HIV Infections/DRUG THERAPY/*IMMUNOLOGY  *HIV-1/GENETICS  Lymphocyte
       Transformation  Phenotype  Predictive Value of Tests  Prognosis
       Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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