Document 0087
 DOCN  M9550087
 TI    Mother-to-infant transmission of hepatitis C virus. Lombardy Study Group
       on Vertical HCV Transmission.
 DT    9505
 AU    Zanetti AR; Tanzi E; Paccagnini S; Principi N; Pizzocolo G; Caccamo ML;
       D'Amico E; Cambie G; Vecchi L; Institute of Virology, University of
       Milan, Italy.
 SO    Lancet. 1995 Feb 4;345(8945):289-91. Unique Identifier : AIDSLINE
       MED/95139683
 AB    To assess the risk of mother-to-infant transmission of hepatitis C virus
       (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom
       22 were coinfected with HIV and 94 had HCV alone. None of the babies
       whose mothers had HCV alone acquired HCV, while 8 babies (36%; p <
       0.001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV
       and HIV (3). There was no association between any specific maternal HCV
       genotype and enhanced risk of neonatal infection. HCV-RNA levels were
       significantly higher (p < 0.05) in mothers with HIV coinfection than in
       those with HCV alone. These data indicate that maternal HIV status
       correlates with enhanced level of viraemia which favours neonatal
       infection.
 DE    Adolescence  Adult  Breast Feeding  *Disease Transmission, Vertical
       Female  Follow-Up Studies  Hepatitis Antibodies/BLOOD  Hepatitis
       C/BLOOD/COMPLICATIONS/*TRANSMISSION  Hepatitis C Viruses/IMMUNOLOGY
       Human  HIV Infections/*COMPLICATIONS/TRANSMISSION  Infant, Newborn
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).