Document 0097
 DOCN  M9550097
 TI    Hemostatic disorders in feline immunodeficiency virus-seropositive cats.
 DT    9505
 AU    Hart SW; Nolte I; Clinic of Small Animals, Hanover School of Veterinary
       Medicine,; Germany.
 SO    J Vet Intern Med. 1994 Sep-Oct;8(5):355-62. Unique Identifier : AIDSLINE
       MED/95138904
 AB    The hemostatic function of 40 feline immunodeficiency virus (FIV)
       seropositive and 8 FIV and feline leukemia virus (FeLV) seropositive
       cats was evaluated and compared with reference values from 30 clinically
       healthy cats. The FIV-positive cats were divided into 3 groups: group I
       included asymptomatic carriers; group II comprised sick FIV-infected
       cats with illnesses not likely to influence the hemostatic system; and
       group III included FIV-positive cats with diseases potentially
       associated with coagulopathies. Platelet counts in FIV/FeLV-infected
       cats were significantly lower than in healthy cats (P < .003), whereas
       the differences in the 3 groups of FIV-positive cats were variable
       (group I, P = .009; II, P = .05; III, P = .09). Thrombocytopenia (<
       145,000 platelets/microL) was present in 4 FIV-positive and 3
       FIV/FeLV-positive cats. Platelet aggregation induced by collagen (0.5
       and 0.25 micrograms/mL), adenosine diphosphate (ADP) (1 and 0.6
       mumol/L), and thrombin (0.4 and 0.25 IU/mL) was not significantly
       different from that of healthy cats. The plasma coagulation system was
       evaluated by measuring one-stage prothrombin time (OSPT), activated
       partial thromboplastin time (APTT), thrombin time, fibrinogen
       concentration, coagulation factor assays, fibrinogen and fibrin
       degradation products (FDP), and plasma exchange test. The OSPT was
       similar in FIV-seropositive cats and in the healthy control group. Cats
       with FIV infection, however, had markedly shorter clotting times than
       healthy cats when using a modified test system (P < .05).(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Animal  Blood Coagulation Disorders/IMMUNOLOGY/*VETERINARY  Cat
       Diseases/*IMMUNOLOGY/VIROLOGY  Cats  Factor VIII/ANALYSIS  Feline
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Female
       Fibrinogen/ANALYSIS  Hemostasis  Immunodeficiency Virus,
       Feline/IMMUNOLOGY  Leukemia Virus, Feline/IMMUNOLOGY  Male
       Thrombocytopenia/DIAGNOSIS/VETERINARY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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