Document 0100
 DOCN  M9550100
 TI    Intrathecal synthesis of interleukin-10 (IL-10) in viral and
       inflammatory diseases of the central nervous system.
 DT    9505
 AU    Gallo P; Sivieri S; Rinaldi L; Yan XB; Lolli F; De Rossi A; Tavolato B;
       Institute of Neurology, University of Padua School of Medicine,; Italy.
 SO    J Neurol Sci. 1994 Oct;126(1):49-53. Unique Identifier : AIDSLINE
       MED/95138731
 AB    The intrathecal synthesis of interleukin 10 (IL-10) was investigated in
       120 paired cerebrospinal fluid (CSF) and serum specimens from patients
       with various inflammatory and non-inflammatory diseases of the central
       nervous system (CNS). IL-10 was not demonstrated in the sera, but
       detectable levels were found in the CSF from: patients with acute viral
       (aseptic) meningitis, but only within 48-72 h of symptom onset; human
       immunodeficiency virus type 1 (HIV)-infected patients with HIV-related
       encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient
       with primary B cell lymphoma of the CNS, and a patient with
       encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all
       CSF collected over a period of 6-months). In chronic meningeal
       infections/inflammations, IL-10 seems to be continuously produced within
       the CSF. Our findings suggest that IL-10, a cytokine which exerts many
       immunosuppressive actions, may play different immunomodulatory roles in
       CNS diseases; in particular, its intrathecal synthesis may explain why
       some infectious and inflammatory meningeal diseases may have slow
       development and chronic evolution.
 DE    Adult  Amyotrophic Lateral Sclerosis/BLOOD/CEREBROSPINAL FLUID/
       IMMUNOLOGY  AIDS Dementia Complex/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY
       AIDS-Related Opportunistic Infections/BLOOD/CEREBROSPINAL FLUID/
       IMMUNOLOGY  Central Nervous System Diseases/BLOOD/*CEREBROSPINAL FLUID/
       IMMUNOLOGY  Central Nervous System Neoplasms/BLOOD/CEREBROSPINAL FLUID/
       IMMUNOLOGY  Cerebrospinal Fluid Proteins/*BIOSYNTHESIS  Child
       Comparative Study  Human  HIV Infections/BLOOD/CEREBROSPINAL
       FLUID/IMMUNOLOGY  HIV-1  Inflammation
       Interleukin-10/*BIOSYNTHESIS/BLOOD/CEREBROSPINAL FLUID
       Meningitis/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY  Meningitis,
       Cryptococcal/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY
       Polyradiculoneuritis/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY
       Sarcoidosis/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY  Support, Non-U.S.
       Gov't  Syphilis/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY  Toxoplasmosis,
       Cerebral/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY  Virus
       Diseases/BLOOD/*CEREBROSPINAL FLUID/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).