Document 0101
 DOCN  M9550101
 TI    Cognitive event-related potentials and brain magnetic resonance imaging
       in HTLV-1 associated myelopathy (HAM).
 DT    9505
 AU    Fukushima T; Ikeda T; Uyama E; Uchino M; Okabe H; Ando M; First
       Department of Internal Medicine, Kumamoto University School; of
       Medicine, Japan.
 SO    J Neurol Sci. 1994 Oct;126(1):30-9. Unique Identifier : AIDSLINE
       MED/95138729
 AB    Auditory and visual cognitive event-related potentials (ERPs) were
       investigated in 14 patients with HTLV-1 associated myelopathy (HAM) and
       in 36 normal controls. In the HAM patients, the latencies of P300 and
       N200 by the auditory tone method were significantly delayed, and N100 by
       the auditory click method was significantly delayed in latency. No
       abnormal ERP components were observed with visual methods. While these
       auditory abnormal ERPs were present in the HAM patients, there was no
       evidence of visual abnormal ERPs. Abnormal lesions on the white matter
       were evident at magnetic resonance imaging (MRI) in 6 (75%) of 8
       patients. There was no correlation between MRI lesions and the
       abnormalities of ERPs, but there was a significant correlation between
       bifrontal index on MRI and P300 amplitudes at Cz and Pz sites by
       auditory tone method. In one patient, atrophy of bilateral parietal
       lobes was seen on MRI and P300 latencies delayed using various methods.
       Therefore, the possibility that electrophysiological cognitive
       impairment in patients with HAM is related to brain atrophy rather than
       to white matter lesions requires attention.
 DE    Adult  Aged  Alcoholism/COMPLICATIONS  Atrophy  Autoimmune
       Diseases/COMPLICATIONS  Brain/*PATHOLOGY  Cognition/*PHYSIOLOGY
       Cognition Disorders/*ETIOLOGY  Drugs  *Evoked Potentials, Auditory
       Evoked Potentials, Auditory, Brain Stem  *Evoked Potentials, Visual
       Female  Human  *Magnetic Resonance Imaging  Male  Middle Age
       Paraparesis, Tropical Spastic/COMPLICATIONS/*PHYSIOPATHOLOGY/
       PSYCHOLOGY  Reaction Time  JOURNAL ARTICLE

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