Document 0127
 DOCN  M9550127
 TI    Anti-IL-4 monoclonal antibody and IFN-gamma administration retards
       development of immune dysfunction and cytokine dysregulation during
       murine AIDS.
 DT    9505
 AU    Wang Y; Ardestani SK; Liang B; Beckham C; Watson RR; Department of
       Family and Community Medicine, University of; Arizona, Tucson 85724.
 SO    Immunology. 1994 Nov;83(3):384-9. Unique Identifier : AIDSLINE
       MED/95137666
 AB    This study was designed to determine if administration of
       anti-interleukin-4 (IL-4) monoclonal antibody (mAb), interferon-gamma
       (IFN-gamma) and their combination after LP-BM5 retrovirus infection of
       female C57BL/6 mice would prevent retrovirus-induction of
       immunosuppression and cytokine dysregulation. Splenic natural killer
       (NK) cell activity, T- and B-cell proliferation, and T-helper type 1
       (Th1) and Th2 cytokine (IL-2, IFN-gamma, IL-5 and IL-10) and monokine
       [IL-6 and tumour necrosis factor-alpha (TNF-alpha)] secretions were
       monitored, as they are usually altered dramatically after murine
       retrovirus infection. Administration of IFN-gamma and anti-IL-4
       significantly prevented retrovirus-induced suppression of splenic NK
       cell activity, and splenic T- and B-cell proliferation. They also
       significantly slowed retrovirus-induced elevation of Th2 cytokine (IL-5
       and IL-10) release and monokine (IL-6 and TNF-alpha) secretion by
       splenocytes. They prevented the loss of Th1 cytokine (IL-2 and
       IFN-gamma) release by splenocytes, and alleviated splenomegaly and
       hypergammaglobulinemia, precursor signs of development of acquired
       immune deficiency syndrome (AIDS). These findings could provide insight
       into the roles of immunomodulator in AIDS treatment as well as the
       mechanisms by which retrovirus infection induces cytokine dysregulation,
       facilitating immunodeficiencies in AIDS.
 DE    Animal  Antibodies, Monoclonal/*ADMINISTRATION & DOSAGE
       Cytokines/*METABOLISM  Interferon-gamma, Recombinant/*ADMINISTRATION &
       DOSAGE  Interleukin-4/*IMMUNOLOGY  Mice  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/*THERAPY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).