Document 0130
 DOCN  M9550130
 TI    IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
 DT    9505
 AU    Cohen SB; Katsikis PD; Feldmann M; Londei M; Kennedy Institute of
       Rheumatology, Sunley Division, Hammersmith,; London.
 SO    Immunology. 1994 Nov;83(3):329-32. Unique Identifier : AIDSLINE
       MED/95137658
 AB    Interleukin-10 (IL-10) has various immunomodulatory actions depending on
       the target cell type. Some of these effects have been shown to be owing
       to its ability to down-regulate surface expression of markers, for
       example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B
       cells. In this report we show that preincubation of IL-10 for 24 hr
       up-regulates expression of the activation marker CD25, but not HLA-DR on
       cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- alpha
       beta and gamma delta T-cell receptor (TCR)-expressing cells. This
       up-regulation of CD25 was accompanied by an increase in the T cells
       IL-2-dependent proliferative response in 63% of the CD4+ clones and 100%
       of the CD8+, CD4-, CD8- alpha beta and gamma delta TCR+ clones analysed.
       IL-10 was also shown to be at least partly responsible for the
       up-regulation of CD25 on mitogen-activated peripheral blood mononuclear
       cells, suggesting that IL-10 has this CD25 modulatory effect within a
       more physiological environment. Our data suggest that IL-10 can have a
       multitude of effects on human T cells, and should not be considered
       exclusively as an immunoinhibitory cytokine.
 DE    *Adjuvants, Immunologic  Cell Division/IMMUNOLOGY  Cells, Cultured
       Clone Cells  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Human  HLA-DR Antigens/IMMUNOLOGY
       Interleukin-10/*IMMUNOLOGY  Interleukin-2/IMMUNOLOGY  Lymphocyte
       Transformation/IMMUNOLOGY  Receptors, Antigen, T-Cell,
       alpha-beta/IMMUNOLOGY  Receptors, Antigen, T-Cell,
       gamma-delta/IMMUNOLOGY  Receptors, Interleukin-2/*IMMUNOLOGY
       T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY  Up-Regulation (Physiology)  JOURNAL
       ARTICLE

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