Document 0132
 DOCN  M9550132
 TI    CD4+ T cells are essential in overcoming experimental murine measles
       encephalitis.
 DT    9505
 AU    Finke D; Liebert UG; Institut fur Virologie und Immunbiologie,
       Universitat; Wurzburg, Germany.
 SO    Immunology. 1994 Oct;83(2):184-9. Unique Identifier : AIDSLINE
       MED/95137635
 AB    Clinical observations and experimental animal models have stressed the
       importance of the cellular immune response in the recovery from measles
       virus infection. However, the relative contribution of different T-cell
       subsets to viral elimination is controversial. The aim of the present
       study was to define the components of the immune system which contribute
       to the control of measles virus infection. For this purpose the effect
       of in vivo depletion of CD4+ and/or CD8+ T lymphocytes in the murine
       model of experimental acute measles encephalitis was monitored with
       respect to disease manifestation, survival, neuropathological changes,
       virus elimination from brain, and antiviral antibody titre. In measles
       virus-resistant BALB/c mice removal of the CD8+ T-cell subset did not
       interfere with the clearance of virus from the brain. In contrast,
       depletion of CD4+ T cells rendered BALB/c mice susceptible to infection.
       Also, in measles virus-susceptible C3H mice CD4+ T cells played a role
       in recovery from measles infection, but seemed not to be as effective as
       CD4+ T cells from resistant BALB/c mice. The data indicate that CD4+ T
       cells are essential for protection against measles virus-infection of
       the central nervous system.
 DE    Animal  Antibodies, Viral/BIOSYNTHESIS  Cells, Cultured  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Disease Models, Animal  Encephalitis, Viral/*IMMUNOLOGY  Immune
       Tolerance  Measles/*IMMUNOLOGY  Measles Virus/IMMUNOLOGY  Mice  Mice,
       Inbred BALB C  Mice, Inbred C3H  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).