Document 0150
 DOCN  M9550150
 TI    [Pulmonary mucormycosis in an HIV-infected patient]
 DT    9505
 AU    Harloff KJ; Stoehr A; Wasmuth R; Plettenberg A; Harten J; Medizinische
       Abteilung, Allgemeines Krankenhaus St. Georg,; Hamburg.
 SO    Dtsch Med Wochenschr. 1995 Jan 27;120(4):94-8. Unique Identifier :
       AIDSLINE MED/95136878
 AB    A 51-year-old man, known to have chronic-aggressive hepatitis B, HIV
       infection and exertional dyspnoea, was hospitalized because of acute
       physical deterioration, cough with whitish exudate and dyspnoea at rest.
       Despite a CD4/CD8 ratio of 0.16 no prophylactic measures against
       Pneumocystis carinii had been taken. On examination the lungs were
       unremarkable, but the liver was enlarged and there were petechiae over
       all parts of the body. Laboratory tests showed impaired liver functions
       and a rise in lactate dehydrogenase activity (538 U/l). Chest radiogram
       demonstrated small to very small infiltrates in the lung. As
       Pneumocystis carinii pneumonia was suspected but bronchoscopy was too
       risky, he was at first treated with trimethoprim/sulphamethoxazole (four
       times 320/1600 mg/24 h intravenously). When this failed, he received
       pentamidine (4 mg/kg, after 4 days 2 mg/kg intravenously), and finally
       cefotiam (twice 2 g daily), tobramycin (three times 40 mg daily) and
       corticoids (100 mg). Despite this treatment he died after 10 days from
       respiratory failure. Autopsy revealed interstitial pneumonia throughout
       the lung as well as focal mucor infiltrations in the wall of
       middle-calibre lung veins. Mucor is a ubiquitous, facultatively
       pathogenic mold fungus.
 DE    *AIDS-Related Opportunistic Infections  Case Report  Diagnosis,
       Differential  English Abstract  Fatal Outcome  Human  HIV
       Infections/*COMPLICATIONS  Lung/MICROBIOLOGY  Lung Diseases,
       Fungal/*COMPLICATIONS  Male  Middle Age  Mucormycosis/*COMPLICATIONS
       Pneumonia, Pneumocystis carinii/DIAGNOSIS  JOURNAL ARTICLE

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