Document 0156
 DOCN  M9550156
 TI    Immunologic disturbances and levels of parathyroid hormone in uremic
       patients in replacement dialysis therapy.
 DT    9505
 AU    Angelini D; Carlini A; Mazzotta L; Mei E; Grassi R; Giusti R; Neri M;
       Fiorini I; Antonelli A; Department of Nephrology, Hospital of Lucca,
       Italy.
 SO    Clin Nephrol. 1994 Oct;42(4):246-50. Unique Identifier : AIDSLINE
       MED/95136540
 AB    We studied the changes in cellular immunity in patients in replacement
       dialysis therapy (RDT) and examined the relationship between
       T-lymphocyte function and plasma levels of parathyroid hormone (PTH). In
       a preliminary study we found that increased plasma levels of PTH were
       associated with a decrease of T-lymphocytes and CD4, an increase in CD8
       and a reduction in the ratio of CD4 to CD8. In the present study we
       examined the relationship between plasma levels of PTH, interleukin 2
       receptors (IL-2R) and soluble human CD8 (S-CD8). We studied 54 patients
       divided into two groups: 26 patients with normal levels of PTH and 28
       patients with increased levels of PTH. We found a significant reduction
       in total T-lymphocytes in both groups as compared to controls, with an
       inverse correlation between total T-lymphocytes and plasma PTH in the
       second group (R = -0.52). There was an increase in IL-2R in the group II
       as compared to the controls and also in the total population of uremic
       patients with a linear correlation between levels of IL-2R and PTH (R =
       0.6). The levels of S-CD8 showed a significant increase in both groups
       with a linear correlation between levels of SC-D8 and PTH (R = 0.63). No
       specific differences were seen between patients treated with and without
       1,25-dihydroxyvitamin D3. The elevated levels of PTH affect the
       lymphocyte function and are associated with change in cellular immunity
       with reduction in total number of T cells, and increases in levels of
       CD8, S-CD8 and IL-2R.
 DE    Adult  Aged  Antigens, CD8/ANALYSIS  Comparative Study  CD8-Positive
       T-Lymphocytes  Female  *Hemodialysis  Human  Hyperparathyroidism,
       Secondary/*IMMUNOLOGY  Immunity, Cellular/IMMUNOLOGY  Immunoenzyme
       Techniques  Lymphocyte Count  Male  Middle Age  Parathyroid
       Hormones/*BLOOD  Receptors, Interleukin-2/ANALYSIS  T-Lymphocyte Subsets
       T-Lymphocytes/*IMMUNOLOGY  Uremia/BLOOD/*IMMUNOLOGY/THERAPY  JOURNAL
       ARTICLE

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