Document 0182
 DOCN  M9550182
 TI    Illness stage, concurrent medications, and other correlates of low
       testosterone in men with HIV illness.
 DT    9505
 AU    Wagner G; Rabkin JG; Rabkin R; New York State Psychiatric Institute,
       College of Physicians and; Surgeons, Columbia University, New York
       10032.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):204-7.
       Unique Identifier : AIDSLINE MED/95136000
 AB    Our objective was to assess whether illness stage, markers of illness
       progression, and use of medications believed to lower testosterone are
       associated with low serum testosterone in HIV+ men. Data were available
       for 234 HIV+ men screened for eligibility for a study of testosterone
       replacement therapy and/or an antidepressant trial. A screening
       interview was used to elicit demographic and medical information. Blood
       was drawn to measure markers of immunodeficiency and serum testosterone.
       Thirty-eight percent of the sample had testosterone levels below the
       normal range. Low testosterone was associated with lower CD4 cell count,
       later stage of illness, use of megestrol, and older age. Regression
       analysis showed that only age and use of such medications as megestrol
       were significant predictors of low testosterone. Given the prevalence of
       low testosterone in HIV+ men and its link to sexual dysfunction, more
       research is needed on treatments aimed at correcting or compensating for
       this hormonal deficiency as well as the study of the impact of such
       medications as megestrol on testosterone levels in older men.
 DE    beta 2-Microglobulin/ANALYSIS  Adult  Aged  Antiviral Agents/THERAPEUTIC
       USE  Child  Human  HIV Infections/CLASSIFICATION/DRUG
       THERAPY/*METABOLISM  Male  Middle Age  Regression Analysis  Support,
       U.S. Gov't, P.H.S.  T-Lymphocyte Subsets
       Testosterone/*BLOOD/*DEFICIENCY  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).