Document 0184
 DOCN  M9550184
 TI    Disseminated Mycobacterium avium infection among HIV-infected patients
       in Kenya.
 DT    9505
 AU    Gilks CF; Brindle RJ; Mwachari C; Batchelor B; Bwayo J; Kimari J; Arbeit
       RD; von Reyn CF; Clinical Research Centre, Kenya Medical Research
       Institute,; Nairobi.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):195-8.
       Unique Identifier : AIDSLINE MED/95135998
 AB    Previous studies from Africa have been unable to identify disseminated
       Mycobacterium avium complex (MAC) infection in patients with advanced
       human immunodeficiency virus (HIV) infection. We performed mycobacterial
       blood cultures and CD4 counts on 48 symptomatic adults with advanced HIV
       infection admitted to the hospital in Nairobi, Kenya over 4 weeks in
       1992. Fourteen patients had mycobacteremia; these patients had
       significantly lower CD4 counts than the patients with negative cultures
       (14/mm3 vs. 85/mm3; p < 0.01). Three patients (6%) were bacteremic with
       M. avium (mean CD4 count, 10/mm3) and 11 (23%) were bacteremic with
       Mycobacterium tuberculosis complex (MTB) (mean CD4 count, 15/mm3). Thus,
       M. avium bacteremia was detected significantly less frequently in the
       study population than MTB bacteremia (p = 0.04). The minimum rate for
       HIV-associated disseminated M. avium infection in patients admitted to
       the hospital in Nairobi was estimated to be approximately 1%. Patients
       with mycobacteremia died or were discharged home sick before the
       diagnosis was made. Disseminated M. avium does occur in adults with
       advanced HIV infection in sub-Saharan Africa, but is less common than
       disseminated MTB.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/MORTALITY  Adult
       Bacteremia  CD4 Lymphocyte Count  Female  Human  Kenya  Male
       *Mycobacterium avium Complex  Mycobacterium avium-intracellulare
       Infection/*BLOOD/  *COMPLICATIONS/MORTALITY  Prevalence  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Tuberculosis/BLOOD/COMPLICATIONS/MORTALITY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).