Document 0186
 DOCN  M9550186
 TI    Predictive markers for mother-to-child transmission of HIV-1 in Dar es
       Salaam, Tanzania.
 DT    9505
 AU    Bredberg-Raden U; Urassa W; Urassa E; Lyamuya E; Msemo G; Kawo G;
       Kazimoto T; Massawe A; Grankvist O; Mbena E; et al; Department of
       Immunology, Swedish Institute for Infectious; Disease Control,
       Stockholm.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):182-7.
       Unique Identifier : AIDSLINE MED/95135996
 AB    The aim of this study was to determine immunological factors associated
       with increased risk of mother-to-child transmission of HIV-1 that could
       be used as predictive markers in Tanzanian women. One hundred and
       thirty-eight HIV-1-seropositive and 117-seronegative mothers and their
       newborns were recruited at delivery and followed up at Muhimbili Medical
       Centre in Dar es Salaam, Tanzania. Blood specimens from the mothers were
       analyzed for HIV-1 p24 antigen, beta 2-microglobulin (B2M), T-lymphocyte
       subsets, and presence of viral DNA in blood mononuclear cells by the
       polymerase chain reaction (PCR). Among 138 seropositive mothers, 30
       (21.7%) had transmitted HIV-1 to their children, as shown by a positive
       PCR in the child. The vertical transmission rate was significantly
       higher in women with a percentage of CD4 lymphocytes < or = 20 (eight of
       24, 33%) or a level of B2M > or = 2 mg/L (21 of 62, 34%) than in women
       with a higher percentage of CD4 lymphocytes (10 of 73, 14%) or a lower
       level of B2M (eight of 57, 14%) (p = 0.034 and 0.018, respectively). In
       eight of 18 (44%) transmitting mothers the percentage of CD4 lymphocytes
       was < or = 20, and in 21 of 29 (72%) transmitting mothers the B2M level
       was > or = 2 mg/L. In women with both a low percentage of CD4
       lymphocytes (< or = 20) and a high level of B2M (> or = 2 mg/L), the
       vertical transmission rate was 54%.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    beta 2-Microglobulin/ANALYSIS  Biological Markers  *Disease
       Transmission, Vertical  Enzyme-Linked Immunosorbent Assay  Female  Human
       HIV Core Protein p24/BLOOD  HIV
       Seropositivity/EPIDEMIOLOGY/*TRANSMISSION  *HIV-1  Infant  Infant,
       Newborn  Polymerase Chain Reaction  Pregnancy  Support, Non-U.S. Gov't
       T-Lymphocyte Subsets  Tanzania  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).