Document 0187
 DOCN  M9550187
 TI    The duration of breastfeeding by HIV-1-infected mothers in developing
       countries: balancing benefits and risks.
 DT    9505
 AU    Nagelkerke NJ; Moses S; Embree JE; Jenniskens F; Plummer FA; Department
       of Medical Microbiology, University of Nairobi, Kenya.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):176-81.
       Unique Identifier : AIDSLINE MED/95135995
 AB    How best to advise mothers infected with human immunodeficiency virus
       type 1 (HIV-1) in developing countries regarding breastfeeding is an
       important issue that has generated considerable debate. Previous studies
       have addressed this problem by means of mathematical models, but without
       considering the issue of the duration of breastfeeding. A mathematical
       model was developed to compare the age-specific risks of mother-to-child
       HIV transmission versus the excess mortality due to not breastfeeding.
       In this model it is assumed that both the risk of mother-to-child
       transmission of HIV through breast milk and the relative risk of not
       breastfeeding do not vary with age. The model indicates that, in
       HIV-1-seropositive mothers, the decrease in child mortality afforded by
       breastfeeding may exceed the risk of mother-to-child HIV-1 transmission
       only during the first 3-7 months of life. Thereafter the risk of HIV-1
       transmission probably exceeds the mortality benefit of breastfeeding.
       Experimental studies of counselling HIV-1-infected mothers to limit
       their duration of breastfeeding should be considered in the setting of
       developing countries.
 DE    *Breast Feeding  *Developing Countries  *Disease Transmission, Vertical
       Female  Human  HIV Infections/EPIDEMIOLOGY/*TRANSMISSION  Infant
       Infant, Newborn  *Models, Biological  Pregnancy  Risk Factors  Support,
       Non-U.S. Gov't  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).