Document 0212
 DOCN  M9550212
 TI    The use of antibiotics in the treatment and prevention of infection in
       HIV-infected children.
 DT    9505
 AU    Ruga E; Giaquinto C; Cozzani S; Giacomelli A; Pagliaro A; Mazza A; De
       Manzini A; Laverda AM; D'Elia R; Department of Paediatrics, University
       of Padua, Italy.
 SO    Acta Paediatr Suppl. 1994 Aug;400:70-2. Unique Identifier : AIDSLINE
       MED/95135024
 AB    Children with HIV infection have an unusual susceptibility to bacterial
       infection, related to several immune abnormalities. Selection of initial
       antibiotic therapy must be individualized in these children. Patients
       with community-acquired disease are most likely to have infection by
       polysaccharide-encapsulated bacterial organism, most commonly
       Streptococcus pneumoniae and less frequently by Haemophilus influenzae
       type b. If it is possible to treat the patients at home, the use of
       amoxicillin-clavulanic acid might be appropriate. Other authors propose
       management with parenteral ceftriaxone because of the better compliance
       and the malabsorption. In hospitalized patients, concern for
       Gram-negative enteric pathogens other than polysaccharide-encapsulated
       organisms requires initial therapy with a third-generation
       cephalosporine in combination with an aminoglycoside.
       Trimethoprim-sulfamethizole is the most common drug used in HIV-infected
       children because it is recommended for the initial therapy and for
       prophylaxis of pneumocystis carinii pneumonia, which occurs in as many
       as 42% of these children.
 DE    AIDS-Related Opportunistic Infections/COMPLICATIONS/*PREVENTION &
       CONTROL  Child  Clinical Trials  Drug Therapy, Combination  Human  HIV
       Infections/*COMPLICATIONS  Sulfamethizole/*THERAPEUTIC USE
       Trimethoprim/*THERAPEUTIC USE  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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       protected by Copyright Law (Title 17, U.S.Code).