Document 0219
 DOCN  M9550219
 TI    HIV mass screening of infants and mothers: historical, technical, and
       practical issues.
 DT    9505
 AU    Grady GF; Theobald Smith Research Institute, State Laboratory
       Institute,; Jamaica Plain, MA.
 SO    Acta Paediatr Suppl. 1994 Aug;400:39-42. Unique Identifier : AIDSLINE
       MED/95135017
 AB    Screening groups of anonymous infants for HIV antibody, as an index of
       maternal infection rates, has been a widely used seroepidemiological
       method since being introduced in 1986 in Massachusetts (USA). One
       shortcoming has been the applicability only to parturient women, thus
       necessitating corrections for fertility rates in extrapolation to all
       women. A second disadvantage has been controversy and confusion about
       the distinction between anonymous seroprevalence studies and linked
       testing. However, there have been major advantages such as the leading
       indicator nature of the data obtained. Experience with screening nearly
       a half million Massachusetts newborns through December 1992 has shown
       seroprevalence rates stabilizing at 2.4 per 1000, and with consistent
       10-fold differences between groups of birth hospitals serving different
       socio-economically defined populations. In addition to predicting the
       future of the AIDS epidemic in children, the information provides a
       reference point for comparing the completeness of targeted
       identifications of HIV infection in mothers and infants.
 DE    Comparative Study  Female  Human  HIV
       Infections/EPIDEMIOLOGY/IMMUNOLOGY/*PREVENTION & CONTROL  *HIV
       Seroprevalence  Infant, Newborn  Male  *Mass Screening
       Massachusetts/EPIDEMIOLOGY  *Mothers  Neonatal Screening  North
       Carolina/EPIDEMIOLOGY  Pilot Projects  Rural Population  Socioeconomic
       Factors  Suburban Population  Support, U.S. Gov't, P.H.S.  Urban
       Population  JOURNAL ARTICLE

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