Document 0221
 DOCN  M9550221
 TI    Autoimmune phenomena in children with human immunodeficiency virus
       infection and acquired immunodeficiency syndrome.
 DT    9505
 AU    Rodriguez-Mahou M; Lopez-Longo J; Lapointe N; Carreno L; Grau R;
       Gurbindo D; Fernandez-Cruz E; Department of Immunology, Hospital General
       Universitario Gregorio; Maranon, Madrid, Spain.
 SO    Acta Paediatr Suppl. 1994 Aug;400:31-4. Unique Identifier : AIDSLINE
       MED/95135015
 AB    We have studied sera from 44 children with Human Immunodeficiency Virus
       infection and Acquired Immunodeficiency Syndrome using immunoblotting,
       radioimmunoassay, enzymoimmunoassay and indirect immunofluorescence. We
       have detected a low incidence of antinuclear (2.9%), anti-reticulin
       (2.9%) and anti-smooth muscle (14.7%) antibodies by indirect
       immunofluorescence. By enzymoimmunoassay we have detected anti-dsDNA
       (20.5%) and anti-ENA [anti-nRNP (61.3%), anti-Sm (29.5%), anti-Ro
       (47.7%) and anti-La (18.1%)] antibodies. Tests for anti-dsDNA by
       radioimmunoassay were negative, suggesting the presence of low-avidity
       anti-DNA antibodies. By immunoblotting we have detected anti-C (nRNP)
       (33.3%), anti-BB' (Sm) (33.3%), anti-Ro (60 KD) (4.5%) and anti-La
       (11.3%) antibodies. The presence of anti-Ro antibodies was associated
       with progressive neurological disease. Long-term follow-up studies with
       larger numbers of patients are necessary to evaluate the clinical
       significance of the presence of anti-dsDNA and anti-ENA antibodies in
       children infected with Human Immunodeficiency Virus.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/GENETICS/IMMUNOLOGY
       Antibodies, Antinuclear/BLOOD/IMMUNOLOGY
       Autoantibodies/BLOOD/*IMMUNOLOGY  *Autoimmunity  Case-Control Studies
       Child  Child, Preschool  DNA, Viral/*ANALYSIS  Follow-Up Studies  Human
       HIV Infections/BLOOD/GENETICS/*IMMUNOLOGY  *HIV-1  Infant
       Isoantibodies/BLOOD/IMMUNOLOGY  Polymerase Chain Reaction
       Ribonucleoproteins, Small Nuclear/BLOOD/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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