Document 0222
 DOCN  M9550222
 TI    Application of the polymerase chain reaction for the detection of HIV in
       specimens from newborn screening programs.
 DT    9505
 AU    Comeau AM; Theobald Smith Research Institute, Inc., State Laboratory;
       Institute, Jamaica Plain, MA.
 SO    Acta Paediatr Suppl. 1994 Aug;400:29-30. Unique Identifier : AIDSLINE
       MED/95135014
 AB    The use of the polymerase chain reaction (PCR) permits detection of HIV
       proviral DNA in the universally collected dried blood spot specimens of
       newborn screening programs. Detection of HIV proviral DNA among the
       annual cohorts of seropositive specimens from ongoing anonymous newborn
       HIV seroprevalence studies can provide a laboratory-based estimate of
       maternal-infant transmission rates. Preliminary data suggest that
       maternal-infant transmission rates may be higher in areas where the
       newborn seroprevalence rates are highest.
 DE    Disease Transmission, Vertical  DNA, Viral/*ANALYSIS  Human  HIV
       Seropositivity/BLOOD/*DIAGNOSIS/GENETICS/TRANSMISSION  Infant, Newborn
       *Neonatal Screening  *Polymerase Chain Reaction  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).