Document 0246
 DOCN  M9550246
 TI    Increased levels of soluble CD8 and CD4 in patients with infectious
       mononucleosis.
 DT    9505
 AU    Yoneyama A; Nakahara K; Higashihara M; Kurokawa K; First Department of
       Internal Medicine, Faculty of Medicine,; University of Tokyo, Japan.
 SO    Br J Haematol. 1995 Jan;89(1):47-54. Unique Identifier : AIDSLINE
       MED/95134680
 AB    Plasma levels of soluble CD8 (sCD8) and soluble CD4 (sCD4) in 44
       patients with infectious mononucleosis (IM) were studied. A marked
       increase in sCD8 (22366 +/- 2702 U/ml; control: 219 +/- 10 U/ml; P <
       0.0001) and significant increase in sCD4 (19.3 +/- 0.9; control: 8.1 +/-
       0.2, P < 0.0001) strongly suggest activation of both CD8+ and CD4+
       lymphocytes, which is important in restraining Epstein-Barr
       virus-infected B lymphocytes. Levels of sCD8 strongly correlated with
       the percentage and the absolute number of both CD8+ and CD8(+)-HLA-DR+
       lymphocytes. In addition, we showed increased release of sCD8 from
       lymphocytes in vitro and increased ratio between plasma sCD8 and the
       number of CD8+ lymphocytes in blood, indicating that elevation of plasma
       sCD8 is due to expansion of CD8+ subset as well as increased sCD8
       release from each CD8+ cell. Increased sCD4 release from CD4+
       lymphocytes, the number of which is not increased in the blood during
       IM, was also seen. Patients with more severe fever had higher levels of
       sCD8 and sCD4. During convalescence sCD8 and sCD4 levels showed
       progressive decrease; however, even at 60-119 d after onset the levels
       of sCD8 and sCD4 remained higher than normal, suggesting prolonged
       lymphocyte activation. These results suggest that sCD8 and sCD4 are
       useful in monitoring immune activation during IM.
 DE    Acute Disease  Adolescence  Adult  Antigens, CD4/*BLOOD  Antigens,
       CD8/*BLOOD  Cells, Cultured  Child  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Fluorescent Antibody Technique  Human  HLA-DR Antigens/BLOOD  Infectious
       Mononucleosis/*IMMUNOLOGY  Longitudinal Studies  Lymphocyte Count
       Lymphocyte Transformation/IMMUNOLOGY  Solubility  JOURNAL ARTICLE

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