Document 0473
 DOCN  M9550473
 TI    Use of cross-reactive antigens of the microsporidian Glugea atherinae
       for the possible detection of Enterocytozoon bieneusi by western blot.
 DT    9505
 AU    Ombrouck C; Romestand B; da Costa JM; Desportes-Livage I; Datry A; Coste
       F; Bouix G; Gentilini M; Unite INSERM 313, CHU Pitie-Salpetriere, Paris,
       France.
 SO    Am J Trop Med Hyg. 1995 Jan;52(1):89-93. Unique Identifier : AIDSLINE
       MED/95160223
 AB    The microsporidia Enterocytozoon bieneusi is reported in 10-30% of those
       infected with the human immunodeficiency virus. The parasite appears to
       be a cause of gastralgia, malabsorption, and diarrhea. A Western blot
       technique using another microsporidian species, Glugea atherinae, has
       demonstrated an antigenic similarity between this parasite and E.
       bieneusi. Preliminary results show the variability of the antigenic
       profiles obtained from the sera of immunodeficient patients infected
       with E. bieneusi and also of the cross-reactivity to Glugea sp. antigens
       of some sera from patients with cryptosporidiosis. The origin of this
       cross-reactivity is undetermined. The possibility of coinfection with
       undetected microsporidia is not excluded. These results raise questions
       concerning the interpretation of serologic data and of the potential
       immunodiagnostic value of microsporidian antigens.
 DE    Animal  Antibodies, Protozoan/BIOSYNTHESIS/IMMUNOLOGY  Antigens,
       Protozoan/*IMMUNOLOGY  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/PARASITOLOGY  Blotting, Western  Cross Reactions
       Cryptosporidiosis/IMMUNOLOGY  Fishes  Human  Immune Sera/IMMUNOLOGY
       Microspora Infections/*DIAGNOSIS/PARASITOLOGY
       Microsporida/*IMMUNOLOGY/ISOLATION & PURIF  Rabbits  Spores/IMMUNOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).