Document 0474
 DOCN  M9550474
 TI    Sequence and phylogenetic analyses of human T cell lymphotropic virus
       type 1 from a Brazilian woman with adult T cell leukemia: comparison
       with virus strains from South America and the Caribbean basin.
 DT    9505
 AU    Song KJ; Nerurkar VR; Pereira-Cortez AJ; Yamamoto M; Taguchi H; Miyoshi
       I; Yanagihara R; Laboratory of Central Nervous System Studies, National
       Institute; of Neurological Disorders and Stroke, National Institutes of;
       Health, Bethesda, Maryland.
 SO    Am J Trop Med Hyg. 1995 Jan;52(1):101-8. Unique Identifier : AIDSLINE
       MED/95160207
 AB    Human T cell lymphotropic virus type 1 (HTLV-1) is endemic in South
       America and the Caribbean basin. To clarify the genetic and phylogenetic
       relationship between an HTLV-1 strain isolated from a Brazilian woman
       with adult T cell leukemia and viral isolates from elsewhere in South
       America and from other geographic regions, selected regions of the gag,
       pol, env, and pX genes were amplified and directly sequenced. The
       overall sequence similarities between the Brazil-R-1 strain and the
       Japanese prototype ATK strain were 98.7% based on 1,295 nucleotides and
       99.1% based on 429 amino acids. Phylogenetic analysis indicated that
       strain Brazil-R-1 clustered with other Brazilian and South American
       HTLV-1 isolates and was more closely related to Caribbean isolates from
       Martinique and Guadeloupe than to virus strains from other geographic
       regions. These data suggest a common source of HTLV-1 infection in the
       Caribbean basin and South America.
 DE    Amino Acid Sequence  Base Sequence  Brazil  Caribbean Region  Case
       Report  Comparative Study  Conserved Sequence  DNA Primers/CHEMISTRY
       Female  Genes, Viral  Human  HTLV-I/CLASSIFICATION/*GENETICS  Leukemia,
       T-Cell/*VIROLOGY  Middle Age  Molecular Sequence Data  *Phylogeny
       Polymerase Chain Reaction  South America  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).