Document 0482
 DOCN  M9550482
 TI    Hypothalamic-pituitary-adrenal axis and immune system.
 DT    9505
 AU    Savastano S; Tommaselli AP; Valentino R; Scarpitta MT; D'Amore G;
       Luciano A; Covelli V; Lombardi G; Chair of Endocrinology, C.E.O.S.
       National Research Council (CNR),; Italy.
 SO    Acta Neurol (Napoli). 1994 Aug;16(4):206-13. Unique Identifier :
       AIDSLINE MED/95159844
 AB    Complex and bidirectional relationships operate between the
       hypothalamic-pituitary-adrenal (HPA) axis and the immune system (IS) and
       either in vivo or in vitro evidence supports a physiological role of the
       HPA axis-IS network. A part of the well-known pharmacological effects of
       glucocorticoid hormones (GC) as immunodepressive agents, the direct
       effects of many HPA axis hormones on IS functions are actually
       documented also in physiologic conditions. Conversely, numerous IS
       soluble mediators are reported to affect the HPA axis functions at
       various steps of HPA axis regulation, in both physiologic and pathologic
       conditions. Stress and aging may represent two paradigmatic conditions
       to show the relevance of the bidirectional network between HPA axis and
       IS, as in both HPA activation and IS impairment are frequently
       coexistent. Finally, in the context of the wide spectrum of HIV-related
       HPA axis abnormalities, a case of a Cushing's syndrome associated to an
       acquired immunodeficiency syndrome (AIDS-related complex) in a
       24-year-old homosexual drug abuser is reported.
 DE    Adult  Animal  AIDS-Related Complex/COMPLICATIONS/PHYSIOPATHOLOGY  Case
       Report  Corticotropin/PHYSIOLOGY  Corticotropin-Releasing
       Hormone/PHYSIOLOGY  Cushing's Syndrome/COMPLICATIONS/PHYSIOPATHOLOGY
       Feedback  Glucocorticoids/*PHYSIOLOGY  Human  Hypothalamo-Hypophyseal
       System/*PHYSIOLOGY  Immune System/*PHYSIOLOGY  Male
       Neuroimmunomodulation/*PHYSIOLOGY  Neurotransmitters/PHYSIOLOGY
       Pituitary-Adrenal System/*PHYSIOLOGY  Rats  Rats, Inbred Lew  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

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